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In addition to their contributions in controlling blood glucose levels, a number of pleiotropic effects have been described for this class of compounds, including the glucose-independent reduction of glomerular hyperfiltration and albuminuria 10,11 and the protective effects in the diabetic kidney disease

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In a small RCT in China (n=39) with patients hospitalised with community-acquired pneumonia, the addition of high dose NAC (1200mg/d for 10 days) to usual care suggested an improvement in oxidative stress parameters, inflammatory factors but not radiological changes compared to usual care only

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