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In human nocturnal sleep, SWS predominates initially and decreases in intensity and duration throughout the course of sleep

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Bi-weekly monitoring of absolute food intake and body weight showed a continuous increase in body weight across all DIO mice groups, including those treated with saline or fed a normal diet, indicating a sustained weight gain trajectory throughout the experimental period (Supplementary Fig

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This dual action creates a physiological pulsatile pattern similar to youthful GH secretion profiles