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OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism

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This resulted in significant amelioration of hepatic inflammation, steatosis, and fibrosis, highlighting the pivotal role of GSDMD-driven pyroptosis in NASH pathogenesis [153]

GLP-1R expression has been reported in brain (25, 26), heart (27, 28), kidney (29) and aorta (26), but the levels (where given) are at least 100-fold lower than in beta cells and in some cases observed in highly enriched sub-fractions (e.g