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Papadimitrakopoulou V, Figlin R, Garland L, Von Hoff D, Kris M, Purdom M, Brown GL, Maack C, Macpherson J and Henner WD

Batch-to-batch consistency is maintained through standardized production and testing protocols, ensuring reliable physicochemical properties such as solubility and stability under defined laboratory conditions

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For example, while use of a relatively low overdose of 200 mg/kg APAP demonstrated protection against liver injury in cyclophilin D-deficient mice [96], only transient protection was achieved when cyclophilin was inhibited using cyclosporine A in vitro [94]

Intensive Care 3 (1), 4