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Heres why: Preventing Under-Eating: Some GLP-1 users find their appetite is so blunted that they barely feel like eating at all

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[1] [2] Gastrointestinal side effects are typically most pronounced during dose escalation and often diminish with continued treatment

Individual Risk Factors for Depression During GLP-1 Treatment Patients with a personal or family history of depression, bipolar disorder, or other mood disorders appear to carry higher risk for mood changes during GLP-1 therapy

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