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The study found that the iron concentration in the vitreous of human OT patients decreased significantly, suggesting that ferroptosis is involved in the pathogenesis of OT (Yamada et al., 2023)

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The released ROS activate the ion channel TRPM2 in macrophages, promoting calcium influx, thereby eliciting an immune response

Environ Res

Possible changes in plasma levels of hepatically metabolized drugs Need for monitoring when used with narrow therapeutic index agents Concomitant administration with antioxidants and vitamin supplements is generally well tolerated, though excessive antioxidant load may blunt physiological redox signaling