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" Executive Summary I
Although there are too few cases to be assessed systematically, there are at least 7 other reported cases of KS associated with JAK inhibitors to date.3 Interestingly, in 3 of these KS cases, regression was seen with discontinuation of the JAK inhibitor without any other therapies, indicating a causal role of JAK inhibitors in the pathogenesis.3 Aside from KS, JAK inhibitors have been associated with an increased risk of malignancy
However, the authors concluded that DMH LepR neurons are not essential for satiation or satiety, as the study found no significant increase in food intake or body weight following inhibition or disruption of these neurons [54]
Additionally, because the SGLT2 transporters also facilitate the reabsorption of sodium from the filtrate there is also the loss of sodium in the urine
This is linked with higher levels of cell damage, which is thought to be a big part in why it develops in the first place (8, 9)
Safety vigilance, thoughtful patient selection, and integration with behavioural care are the practical requirements for translating trial efficacy into real-world benefit
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