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Protein crystal structures were obtained from the RCSB protein databank (rcsb.org) for ACLY (PDB ID 6POF), ACC (PDB ID 5CSK) and FAS (PDB ID 2VZ8) or UniProt (uniprot.org) for CIC (P53007)

Alternatively, oral capsules are available but have significantly lower bioavailability

NNMT is an enzyme primarily found in adipose tissue and the liver, and its role is quite significant

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Impaired adipose expansion caused by liver X receptor activation is associated with insulin resistance in mice fed a high-fat diet

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