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An integrated approach that incorporates chemical modifications, advanced delivery systems, and controlled intracellular release is essential to overcome the inherent instability of RNA therapeutics, paving the way for more effective and long-lasting cancer treatments

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In recent years, numerous studies have shown that the effects of glutamine on the occurrence and development of tumor cells and the functions of nontumor cells should not be underestimated, thus providing theoretical support for the development of cancer therapies that target glutamine metabolism

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Dickinson DA, Levonen AL, Moellering DR, Arnold EK, Zhang H, Darley-Usmar VM, Forman HJ: Human glutamate cysteine ligase gene regulation through the electrophile response element