A.RebbeorJ
The dosing protocols circulating online are extrapolations from preclinical work
10.1046/j.1523-1747.2000.00826.x 190 RadmardA.SaeediM.Morteza-SemnaniK.HashemiS
When used in combination with quercetin, perillyl alcohol can upregulate miR-204, inhibit the SrcSTAT3NFAT pathway, reduce inflammatory cell infiltration, regulate the balance between apoptosis and cell proliferation, and exert anti-oxidative stress effects, thereby improving PH (Rajabi et al., 2020
More commonly used than droxidopa: Midodrine was approved in the 1990s (droxidopa was approved in 2014) Most clinicians have longer experience with midodrine Midodrine is available as a generic & is less expensive Droxidopa is typically reserved for use as an add-on when midodrine is ineffective, or midodrine is not tolerated due to side effects Contraindications: hypertension heart failure acute kidney failure urinary retention thyrotoxicosis pheochromocytoma Side Effects: Supine hypertension WARNING : may cause marked hypertension when the patient is supine (laying down)
The trial was small at 40 people and needs replication, but the result is more than marketing
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