There are indirect costs, too
The optimal duration of Ozempic use for maintaining weight loss after reducing BMI is not fully established
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In contrast, semaglutide, despite its widespread clinical use for glycemic control and weight loss, showed minimal interaction with neurodegenerative pathways within the DM2-AD comorbidity network, suggesting that its metabolic benefits may not translate into AD risk reduction through core disease-associated mechanisms
To improve transparency, an adapted PRISMA-style flow diagram documenting identification, screening, eligibility assessment, de-duplication, and selection of the RCT evidence base and the proof-of-concept Bayesian subset is provided in the Supplementary Appendix Figure 1, together with details of the search strategy, screening process, and data extraction
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