Some individuals report feeling more alert or experiencing difficulty sleeping after taking B12 supplements, particularly high-dose formulations or injections
Mioduchoski, FNP-BC, with physician-supervised care protocols and a focus on safe, individualized treatment planning
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considering the brain and the CNS specifically, BBB penetration rates and the P-glycoprotein (P-gp) efflux pump are critical factors limiting their application in the clinic [1]
However, this does not translate into increased energy in healthy individuals, as research suggests supplementation does not significantly affect energy levels unless a deficiency is present
