A 5 to 8 minute plasma half-life means that by the time subcutaneously injected DSIP is absorbed from the injection site, cleared through lymphatics into venous blood, and circulated, a very substantial fraction has already been enzymatically degraded
As the disease progresses, symptoms worsen, leading to severe memory loss, neuropsychiatric symptoms such as hallucinations and delusions, and intensified behavioral and emotional issues in its advanced stages
However, too much of it can overstimulate the process of detoxification, thus leading to detoxification overload
Future research must navigate the complexity of glial states to precisely target disease-relevant glial subtypes while preserving physiological functions
The most commonly reported side effects are mild and include injection site reactions (redness, pain, swelling) at subcutaneous administration sites, typically transient and manageable with proper injection technique and site rotation
In the end, all versions get metabolized down to the base form of carnitine
