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PMID: 38016844

Wang L, Volkow ND, Kaelber DC, Xu R

Aureane-type sesquiterpene tetraketides inhibit IL-17A secretion by downregulating the transcription factor RORt, and target and inhibit the glycolysis and gluconeogenesis pathways to block energy metabolism in Th17 cells, thereby improving inflammatory responses and vascular smooth muscle cell proliferation in PH (Tang et al., 2023)

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RA20092