Since Fe(II) catalyzes the Fenton reaction to produce the free radical OH * from hydrogen peroxide, its upregulation presents a paradox: Nrf2 also boosts the expression of the genes encoding several components of the ferritin complex that detoxifies Fe(II) by converting it to Fe(III) and then stores it 22
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Common side effects may include localized reactions at the injection site, as well as mild allergic responses
This, combined with the accompanying hypertrophic and neurohormonal changes, significantly increases the susceptibility to severe arrhythmias, including ventricular tachycardia and atrial fibrillation [38, 39]
The peptide simultaneously stimulates production of glycosaminoglycans and collagen around follicles