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No Validated Epithalon Age-Reversal Test Commercial testing before and after Epithalon exposure cannot establish rejuvenation unless the test is validated, the change exceeds normal variation and a controlled comparator is included

All major GLP-1 RA trialsincluding LEADER, SUSTAIN-6, and FLOWwere sponsored by pharmaceutical companies (Novo Nordisk or Eli Lilly), raising the possibility of reporting bias

199 Currently, investigations into GLP-1 RAs and similar drugs are underway to obtain approval for additional indications based on their diverse pharmacological effects

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K-means clustering was performed on the genera relative abundance data using the R script in the Supplementary Materials Scripts .zip file (KMScript), and clusters were plotted

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