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L-ergothioneine has anti-inflammatory properties, which can help to reduce inflammation throughout the body

In some embodiments, the MDT for poloxamer from a formulation or device described herein is at least 10 hours

Keratinocytes interact with immune cells recruited to the site of inflammation and increase the expression of adhesion molecules, which enables immune cells to adhere to the vascular endothelium ( According to the literature, oxidative and nitrosative stress plays a role in the progression of chronic spontaneous urticaria (CSU) ( Table 1 ) (164, 165)

Ursini F, Maiorino M, Gregolin C

This makes it valuable in treatment plans that involve detoxification protocols, especially when paired with nutrition and other therapies that assist in the removal of environmental toxins

doi: 10.1124/mol.117.110841 160 ZayedNAfifHChabaneNMfuna-EndamLBenderdourMMartel-PelletierJet al