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It was designed to treat obesity by targeting peripheral receptors, but some researchers believe it might actually exert its effects through CB1 receptors in the central nervous system 15

This modality of cell death was widely regarded as immunologically silent or even tolerogenic (Krysko and Vandenabeele, 2010)

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Furthermore, new approaches to blockade of signaling mediated by bioactive TNF might have the potential to generate higher-magnitude clinical responses than are currently elicited

Mol Cell Biochem 395(12):110