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The companys HeroPatch technology aims to enable the transdermal delivery of multi-milligram doses and complex formulations of existing therapies and emerging large molecules

Consequently, PANoptosome can be considered a molecular scaffold that houses key proteins capable of activating pyroptosis, apoptosis, and necroptosis, with these proteins playing different roles in the various types of RCD pathways (Fig

Furthermore, the combination of endothelial impairment and oxidative stress may loosen the endothelial junction of the blood-tissue barrier and accelerate the extravascular migration of inflammatory immune cells to the inflamed tissue (Mittal et al., 2014)

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