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A pooled analysis of 5 randomized placebo-controlled trials demonstrated a significant 13% reduction in the risk of total stroke with GLP-1 RAs compared with placebo, without significant heterogeneity between trials

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If successful, semaglutide would be just the second drug the FDA has approved for treatment of MASH

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Mechanistically, erucic acid orchestrates this inhibition by impeding STAT3 phosphorylation and promoting ferroptosis

In addition to claiming revenue of $19.3 billion for the fourth quarter, Eli Lilly executives offered a glimpse into their strategy to expand their GLP-1 franchise into the immunology and inflammation space, with trials currently underway in asthma, psoriatic arthritis, Crohns disease and ulcerative colitis