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intraperitoneal injection of 10 mg/kg [125], drinking water with 25 mM for 1 weeks [158], and dietary supplementation with 1000 ppm for 2 weeks [159]) effectively increased pancreatic MT levels and provided protective outcomes in rats and mice with STZ-induced diabetes, with results ranging from moderate to significant protection

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Phase 3 Progress and Trial Sites in the UK The UK is playing a central role in the TRIUMPH programme, with several academic centers and primary care research sites actively participating in the trials