Retatrutide (development code LY3437943) is a 39-amino acid synthetic peptide developed by Eli Lilly as the first triple-receptor agonist targeting GLP-1R, GIPR, and GCGR in a single molecule
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Obeid R, Andrs E, eka R, Hooshmand B, Guant-Rodriguez RM, Prada GI, Sawek J, Traykov L, Ta Van B, Vrkonyi T, Reiners K, The Vitamin B Consensus Panelists Group
A separate product, semaglutide subcutaneous injection (Wegovy), is indicated as an adjunct to lifestyle modifications for weight loss and chronic weight management in obese (BMI 30 kg/m2 or greater) or overweight adults (BMI 27 kg/m2 or greater) with at least 1 weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)