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Peroxynitrite is interfering with signaling pathways by nitrating protein amino acid residues

56 CORT can activate TRPV1/TRPA1 receptors through oxidative stress or direct receptor interactions, trigger calcitonin gene-related peptide (CGRP) release, promote histamine secretion, impair gastric mucosal barrier function, increase gastric acid permeability, and enhance sensitivity to reflux stimuli

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Thigh: Use the front and outer areas of the thigh, midway between the hip and knee

A switch may be considered because of side effects, organ-protection goals, coverage changes, or insufficient glucose response