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All subjects were informed of the studys aims and provided written consent before they were enrolled in the study

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Hepatic and skeletal muscle insulin sensitivity is best measured via a hyperinsulinemiceuglycemic clamp with glucose tracing techniques

It shouldnt be relied on to treat diabetes

The STEP 1 trial showed weight continued declining until approximately week 60

!Safety note The FDA has reviewed reports of suicidal thoughts or actions with GLP-1 receptor agonists and, in 2026, requested removal of suicidal ideation and behavior warning language from affected GLP-1 labels after finding no increased risk