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Glutathione peroxidase (GPX) catalyzes the reduction of an organic peroxide (ROOH), oxidizing reduced glutathione (GSH) to form disulfde glutathione (GSSG)

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found that exogenous -KG mimics glutaminase-mediated ferroptosis, while using a transaminase inhibitor, amino-oxyacetate (AOA), reverses ferroptosis [85, 86]

Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W