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These combination products can be part of a comprehensive approach to managing constipation alongside other GLP-1 side effects

The overexpression of ROS leads to the polarization of macrophages toward pro-inflammatory M1 phenotype, which secrete interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor- (TNF-) and other inflammation cytokines possessing negative effects on the physiological activities of BMSCs 38

It is not known whether these effects would occur in people

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The mechanism of action of semaglutide mimics the effects of the native hormone GLP-1, which is released in response to food intake