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The researchers found that the mechanism by which metformin stimulates GLP-1 release involves two G-protein-coupled receptors, the M3 cholinergic receptor and the GRP receptor (Mulherin et al., 2011)

doi: 10.5468/ogs.2019.62.4.242 69 JiHZhangZChenCXuWLiuTDongYet al

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This research guide examines growth hormone secretagogues and their mechanisms for stimulating natural GH production through specific receptor pathways

Sadeghi Ataabadi M, Alaee S, Bagheri MJ, Bahmanpoor S