However, the study design did not allow for the assessment of the effects of semaglutide on bone metabolism, independent of weight loss, as the control group did not experience comparable weight reduction
Zepbound: Generally begins at 2.5 mg given once weekly, with the potential to increase by 2.5 mg every 4 weeks until reaching an effective maintenance dose, which can range from 5 mg to 15 mg
First-line therapies, including metformin, sodium-glucose cotransporter-2 inhibitors (SGLT-2i), and Glucagon-like peptide-1 (GLP-1) receptor agonists, are selected according to patient-specific risk factors
Requirements include: Nicotine cessation in all forms Medical optimization Medication review Stable weight At home: Arrange help Prepare meals Plan time off Set up recovery space Scars take 1218 months to mature
Lancet (2014) 384:134957
D-RL, J-YJ, and H-CZ revised the manuscript