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When the demand on GSH increases when more substrate is being conjugated, when the GPx reaction is running faster the cell pulls more heavily on GR and on the upstream synthesis machinery

Curcumin, at doses that achieve a hormetic effect (e.g., 10 mg/L or approximately 28 M in vitro ), can enhance antioxidant defense by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, upregulating glutathione (GSH) metabolism, and inducing glutathione S-transferase (GST) activity, particularly isoforms involved in detoxifying lipid peroxidation products such as 4-hydroxynonenal (4-HNE)

For these reasons, the peptide is commonly included in anti-aging skin products [10, 11]

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Mismatch negativity: an index of a preattentive processing deficit in schizophrenia