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In the Phase 2 trial by Jastreboff et al., 2023, the authors reported a dose-dependent weight reduction of up to -24.2 percent at 48 weeks versus -2.1 percent on placebo across n=338 trial participants

These peptides may support functions such as immune modulation, muscle growth, fat metabolism, and cellular repair

Real-world data from retrospective studies have echoed these findings, though with slightly lower numbers for both medications

Figure 6 illustrates the main efficacy findings from the included RCTs, which are summarized in the subsequent text

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