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However, high expression of SLC7A5 in tumor cells predicts reduced expression of immune-related genes, reduced immune cell infiltration, and poor efficacy of immunotherapy

In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

Institute of Medicine (US) Committee on Nutrition, Trauma, and the Brain

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