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doi: 10.1016/j.jdermsci.2020.08.006 53

weight loss* Semaglutide mimics a natural hormone, GLP-1, to help you feel full and reduce hunger

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The SURMOUNT-5 trial (published in NEJM, 2025) demonstrated mean weight loss of 20.2% with tirzepatide versus 13.7% with semaglutide over 72 weeks in adults with obesity but without diabetes [10]

These results suggest that semaglutide, like other GLP-1RAs, may contribute to promoting healthy lifestyle changes in addition to glycemic control

It has been modified at four specific positions to significantly extend its biological half-life compared to unmodified GHRH