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These dosages are typically given to treat deficiency resulting from pernicious anemia, gastrointestinal disorders (such as Crohns disease), malabsorption syndromes, gastric surgeries and long-term use of medications (such as proton pump inhibitors)

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The pore-forming claudin (CLDN)-2 and barrier forming CLDN-12 seem to be crucial in the Ca 2+ transport through tight junction proteins (17)

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