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This injectable drug works by mimicking the effects of the GLP-1 gastrointestinal hormone, which regulates appetite and promotes a feeling of fullness

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The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-1, but not to glucose-dependent insulinotropic polypeptide, in the portal vein

The dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist tirzepatide improves cardiovascular risk biomarkers in patients with type 2 diabetes: A post hoc analysis

TNF- exerts its effects by activating the intracellular signaling pathway NF-B, further stimulating the multi-protein complex, NOD-like receptor protein 3 (NLRP3) inflammasome ( in the endothelial and vascular smooth muscle cells (13)