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This route is particularly valuable for targeting the central nervous system, as it allows certain peptides and proteins to bypass the bloodbrain barrier (BBB), which typically restricts entry of large or hydrophilic molecules into the brain

Science 289(5482):11971202 Zhang L et al (2003) Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer

This introduces the question of injection volume management

J Anat 2017;230:415

While many people obtain adequate B12 from their diet, some may find it necessary to supplement through injections