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The Bottom Line GHK-Cu sits in a strange spot in the peptide research world genuinely old research (Pickart's earliest work goes back to the 1970s), genuinely broad mechanistic reach (thousands of modulated genes), but still a compound where the human clinical trial base lags behind the mechanistic and cell-culture data

Endotoxin levels should remain below 1 EU/mg for injectable use

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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged