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Accordingly, women who receive hormone replacement therapy are less likely to develop venous leg ulcers or pressure ulcers than untreated controls, and anti-estrogen therapies, such as tamoxifen or aromatase inhibitors, are also correlated with poor wound healing (Thornton, 2013)

In addition, TNF- and IL-6 have also been shown to down-regulate the expression of collagen-I [47]

Published clinical data shows measurable changes in collagen density and skin firmness at 12 weeks of consistent GHK-Cu topical serum use

The peptide appears to promote cell migration and angiogenesis, key processes in tissue repair

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Beyond minoxidil, other topical actives have shown promise in combination: copper peptides (Kuceki 2025) demonstrated significant results in resistant cases, platelet-rich plasma (PRP) has been studied in network meta-analyses, and GHK-Cu serums work through complementary mechanisms