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The Gap Between an Association and an Indication Observational database studies are useful for generating hypotheses and for detecting signals across populations too large to randomise

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Those are useful, but there are serious limitations regarding how benefits to animals can be translated to benefits to people

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Green JB, Bethel MA, Armstrong PW, et al

However, the higher prevalence of PsA in the low BSA group is consistent with recommendations to reserve biologics for patients with more severe disease, including those who may have less skin involvement but burdensome joint symptoms [29]