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All published findings referenced here are based exclusively on animal models and in vitro systems

Maibach HI, Kligman AM

In cells that have significant malic enzyme activity, this enzyme could play a critical anaplerotic role by replenishing oxaloacetate so the TCA cycle can progress

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doi: 10.3760/cma.j.issn.0254-6450.2019.12.014 27 LiLChenJWangJCaiD