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Analysis of the data indicates that short-term treatment with RM-493 increased resting energy expenditure significantly (by 6.4% vs placebo), thus suggesting RM-493 may be clinically effective for treating obesity

10.3892/mmr.2017.8310 102 HuangY.GuoB.ShiB.GaoQ.ZhouQ

PMID: 35 LiangZDiNLiLYangD

These liver IGF-1-deficient mice were crossed with mice that express a mutant GH that acts as an antagonist, and the resulting mice showed improved insulin sensitivity and decreased blood glucose and insulin levels (175)

Separation and identification of catalpol from Rehmannia and its acute toxicity Test

[165] It should be cautioned, however, that a recent study showed a potential adverse interaction