Trials 21 , 520 (2020)
Using peptides as a substitute for rehabilitation rather than a complement to it produces inferior results
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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking
To view a copy of this license, visit About this article Cite this article Alkilany, A.M., Alsotari, S., Alkawareek, M.Y
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