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Prior art literature such as United States Patents US4797284 and US4880633 had employed propylene glycol as a penetration enhancer which is gelled with 2 percent hydroxypropyl guar (HP-60 Jaguar from Celanese) which served as a dissolved drug reservoir

In ethnomedicinal practices, BV has been used to alleviate symptoms of arthritis, rheumatism, and inflammatory conditions

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