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Demonstrated in rat models that combining a GHRP with GHRH produced GH pulse amplitudes 4-to-10-fold greater than GHRH alone [5]

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Methods Data source and ethics This study was approved by the VUMC Institutional Review Board (IRB

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Collectively, the integrated therapeutic strategies targeting ferroptosis, pyroptosis, and necroptosisincluding RCD inducers combined with ICIs, nanotechnology-driven precision delivery systems, and multi-targeted approaches to overcome metabolic plasticity and off-target toxicitiesprovide a comprehensive framework to enhance melanoma immunotherapy efficacy ( Figure 4 )

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