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Data availability The AH helical wheel was generated using PMIpred[ The protein structure data used in this study are available in the PDB database: Mouse SNX1 6-fold (7D6D), Mouse SNX1 7-fold (7D6E), and Fungi Vps5 (6H7W)

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This hints that the redox potential of the flavin is likely similar to that of NADPH and the variants modulate the balance of forward or reverse hydride transfer rates resulting in varied extents of flavin reduction

The SELECT trial (Lincoff et al., NEJM 2023, NCT03574597) extended Semaglutide research to cardiovascular outcomes in 17,604 adults with obesity and prior cardiovascular disease (no T2D) over a mean ~34-month follow-up

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