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However, our in vitro analysis in MIN6 cells showed that expression of PPAR-, GLP-1R, and GIPR were reduced after 24-h treatments with 1-mM metformin in the presence of 5.5 mM glucose (data not shown)

References Institute of Medicine (US) Subcommittee on Military Weight Management

Summary: The Future of GH Secretagogue Research Growth hormone secretagogues represent an approach to hormonal optimization that works with natural physiology rather than replacing endogenous hormones

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