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Besides, metabolic reprogramming and epigenetic modifications interact with each other, enabling further tumor progression [241]

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[31] AGEs absorb and provide a little protection against some of the damaging factors of UV (up to SPF 3), [32] [33] However, they do not have melanin's extended electronic structure that dissipates the energy, so part of it goes towards starting free radical chain reactions instead, in which other AGEs participate readily

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