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Keywords: Glutathione, Oral bioavailability, N-acetyl cysteine, Oxidative stress, Metabolic syndrome, Dietary supplement, Nutraceuticals, Sublingual Graphical abstract Highlights Oral GSH is known for its poor bioavailability in humans

Vitamins C, B6, and B1 are essential for maintaining energy metabolism, immune defense, and nervous system health

Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia

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Proper Timing and Dosage When Medically Approved If your oncologist says its okay to take Vitamin B12, follow their advice on when and how much

JX: Data curation, Funding acquisition, Writing review & editing