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However, since some effects, such as those on inflammation, were only observed in SD-fed subjects, it is possible that the dose was not high enough to counteract the effects of the WD, and a higher dose may have led to reductions in WD-fed rats

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FIGURE 1 Dysregulation of the IGF-1 signaling pathway has been implicated in a variety of aging-related diseases including muscle disease, cardiovascular diseases (CVDs), neurodegenerative diseases, metabolic diseases, and cancer (Zha and Lackner, 2010