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S2CID 237485915

doi:10.1038/sj.jid.5700289

This is a narrative review that critically synthesizes preclinical and clinical evidence on the age-dependent effects of tetrahydrocannabinol (THC) and cannabidiol (CBD), with particular emphasis on dose, route of administration, and pharmacokinetic constraints imposed by aging

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Patch-clamp on pyramidal cells to characterise intrinsic properties (rheobase, adaptation, afterhyperpolarisation)

This effect is believed to be due to IGF-1 suppression of insulin secretion, which leads to augmented lipolysis in adipose tissue and promotion of FFA use by muscle