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Aggrecan-binding peptide Aggrecan, an abundant ECM molecule in cartilages, is characterized by a high fixed charge density attributed to numerous chondroitin and keratan sulfate moieties

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Although high peripheral exposure may be required to obtain the fractional central exposure necessary to illicit a pharmacologic response, insufficient selectivity between MC1R and MC4R activity can lead to peripheral activation of MC1R (142, 143)